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Therapie. 2016 Oct 27. pii: S0040-5957(16)30054-3. doi: 10.2515/therapie/2015053. [Epub ahead of print]

[Red yeast-rice-induced muscular injuries: Analysis of French pharmacovigilance database and literature review].

[Article in French]

Author information

1
Département de pharmacologie médicale et toxicologie, centre régional de pharmacovigilance et d'information sur le médicament, hôpital Lapeyronie, CHU Lapeyronie, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 5, France. Electronic address: c-philibert@chu-montpellier.fr.
2
Département de pharmacologie médicale et toxicologie, centre régional de pharmacovigilance et d'information sur le médicament, hôpital Lapeyronie, CHU Lapeyronie, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 5, France.
3
Centre régional de pharmacovigilance et d'information sur le médicament, hôpital Sainte-Marguerite, 13009 Marseille, France.
4
Centre régional de pharmacovigilance et d'information sur le médicament, hôpital Nord, CHU de Saint-Étienne, 42270 Saint-Priest-en-Jarez, France.
5
Coordination de pharmacovigilance d'Île-de-France, centre régional de pharmacovigilance et d'information sur le médicament, hôpital de la Pitié-Salpêtrière, 75013 Paris, France.

Abstract

Red yeast rice (RYR) is a dietary supplement containing monacolins obtained by fermentation of Monascus purpureus strains. Because of its structural homology with lovastatin, monacolin K inhibits HMG-CoA reductase and shows hypocholesterolemic properties comparable to synthetic statins. We studied all cases of myopathy involving RYR reported in the French national pharmacovigilance database (6 cases) and in scientific literature (9 cases). Among these cases, 9 showed elevated creatine kinase, 3 rhabdomyolysis and 2 myalgia. Recent studies seem to show good efficacy of the RYR, however, our work reports the existence of related muscular disorders. In addition, dietary supplements currently available on the market may show considerable variability of formulation and/or the presence of contaminants. When clinicobiological disorders occur, physicians should consider the eventual use of an herbal treatment.

KEYWORDS:

Atteintes musculaires; Levure de riz rouge; Muscular injuries; Phytotherapy; Phytothérapie; Red yeast rice; Statin; Statine

PMID:
28277227
DOI:
10.2515/therapie/2015053

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