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Gynecol Endocrinol. 2017 May;33(5):399-404. doi: 10.1080/09513590.2017.1290066. Epub 2017 Feb 21.

TCF7L2, CAPN10 polymorphisms are associated with gestational diabetes mellitus (GDM) risks: a meta-analysis.

Author information

1
a Department of obstetrics three and.
2
b Department of obstetrics one , Cangzhou Central Hospital , Cangzhou , Hebei , PR China.

Abstract

Several polymorphisms have been identified in transcription factor 7-like 2 (TCF7L2), and calpain-10 (CAPN10) genes. Controversial conclusions for the genetic relationship between these polymorphisms and gestational diabetes mellitus (GDM) risks were obtained. Our study aims at assessing whether these polymorphisms are associated with GDM susceptibility via a meta-analysis. A total of 19 eligible case-control articles were obtained after databases searching. A significantly increased GDM risk was observed for TCF7L2 rs7903146 (all OR > 1, p < 0.01), but not rs12255372. In addition, significant difference was observed in case/control comparison for 112/112 (GG/2R2R/TT) haplotype combination frequency of CAPN10 SNP-43/19/63 (OR = 3.32, p = 0.043). In summary, TCF7L2 rs7903146 and 112/112 haplotype of CAPN10 might be associated with GDM risks.

KEYWORDS:

CAPN10; GDM; TCF7L2; meta-analysis

PMID:
28277135
DOI:
10.1080/09513590.2017.1290066
[Indexed for MEDLINE]

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