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Ups J Med Sci. 2017 Jun;122(2):71-77. doi: 10.1080/03009734.2017.1285374. Epub 2017 Mar 3.

Development of new levodopa treatment strategies in Parkinson's disease-from bedside to bench to bedside.

Author information

1
a Department of Neuroscience , Neurology, Uppsala University , Uppsala , Sweden.

Abstract

This review will illustrate the process of moving from an idea through preclinical research and Galenic developments into clinical investigations and finally to approval by regulatory agencies within the European Union. The two new treatment strategies described, levodopa/carbidopa intestinal gel and levodopa/carbidopa microtablets, for advanced Parkinson's disease, have been developed in collaborative research within departments at Uppsala University. With this historical approach, reference priority is given to reports considered to be of special importance for this more than two decades long process 'from bedside to bench to bedside'.

KEYWORDS:

Carbidopa; Parkinson’s disease; drug development; intestinal gel; levodopa; microtablets

PMID:
28276779
PMCID:
PMC5441375
DOI:
10.1080/03009734.2017.1285374
[Indexed for MEDLINE]
Free PMC Article

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