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J Nucl Cardiol. 2018 Oct;25(5):1692-1704. doi: 10.1007/s12350-017-0841-z. Epub 2017 Mar 8.

First assessment of simultaneous dual isotope (123I/99mTc) cardiac SPECT on two different CZT cameras: A phantom study.

Author information

1
Department of Nuclear Medicine, UF 5881, Groupement des Hôpitaux de l'Institut Catholique de Lille, Lomme, France. ta.blaire@gmail.com.
2
Normandie Univ, UNICAEN, Signalisation, électrophysiologie et imagerie des lésions d'ischémie-reperfusion myocardique, FHU REMOD-VHF, 14000, Caen, France. ta.blaire@gmail.com.
3
Department of Nuclear Medicine, IRIS, Hôpital Privé Le Bois, Lille, France. ta.blaire@gmail.com.
4
Department of Nuclear Medicine, UF 5881, Groupement des Hôpitaux de l'Institut Catholique de Lille, Lomme, France.
5
Normandie Univ, UNICAEN, Signalisation, électrophysiologie et imagerie des lésions d'ischémie-reperfusion myocardique, FHU REMOD-VHF, 14000, Caen, France.
6
Department of Nuclear Medicine, IRIS, Hôpital Privé Le Bois, Lille, France.
7
Department of Nuclear Medicine, CHU de Montpellier, Montpellier, France.
8
Department of Nuclear Medicine, CHU Cote de Nacre, Caen, France.

Abstract

BACKGROUND:

We studied the impact of simultaneous dual-isotope acquisition on 123I/99mTc mismatch assessment using two CZT cameras (DNM 530c, GE Healthcare and DSPECT, Biosensors International).

METHODS:

We used an anthropomorphic torso phantom (respectively filled with a solution of 123I alone, 99mTc alone, and a mixture of 123I and 99mTc) and its cardiac insert with two defects mimicking two matched and mismatched defects. Mismatch extent and reconstructed image contrast were evaluated.

RESULTS:

The acquisition mode (single vs dual) significantly impacted (i) 99mTc (but not 123I) reconstructed segmental activities using both camera (P < .001), and (ii) image contrast (using 123I and DNM 530c, P < .0001; and using both 123I and 99mTc with DSPECT, P < .0001). However, the defect and mismatch size were not impacted by the type of acquisition. With both DNM 530c and DSPECT, Lin's concordance correlation coefficient and Bland-Altman analysis demonstrated an almost perfect concordance and agreement between single- and simultaneous dual-isotope segmental activity (123I and 99mTc).

CONCLUSIONS:

This study found no impact of the acquisition mode (single vs dual) or the type of camera (DSPECT vs DNM 530c) on 123I and 99mTc defect size and mismatch, providing a new step toward simultaneous dual-isotope acquisition for combined innervation and perfusion assessment.

KEYWORDS:

CZT; DNM 530c; DSPECT; dual isotope; mIBG; mismatch

PMID:
28275896
DOI:
10.1007/s12350-017-0841-z

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