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Clin Res Cardiol. 2017 Aug;106(8):582-589. doi: 10.1007/s00392-017-1090-5. Epub 2017 Mar 8.

Risk for life-threatening arrhythmia in newly diagnosed peripartum cardiomyopathy with low ejection fraction: a German multi-centre analysis.

Author information

1
Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. duncker.david@mh-hannover.de.
2
Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
3
II. Medical Clinic, Department of Electrophysiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
4
Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
5
Lukaskrankenhaus Neuss, Neuss, Germany.
6
Department III of Internal Medicine, University of Cologne, Heart Center, Cologne, Germany.
7
Department of Cardiology, Medical University Hospital, Heidelberg, Germany.
8
Cardioangiologisches Centrum Bethanien, Medizinische Klinik III, Markus Krankenhaus, Frankfurt am Main, Germany.
9
Department of Internal Medicine II, Cardiology, University Hospital Bonn, Bonn, Germany.
10
Department of Internal Medicine I (Cardiology, Angiology, Pneumology and Internal Intensive Care Medicine), University Hospital, RWTH Aachen University, Aachen, Germany.
11
Department of Internal Medicine I, Division of Cardiology, University of Giessen, Giessen, Germany.
12
Praxisklinik Herz und Gefäße, Kardiologie-Angiologie-Radiologie-Nuklearmedizin, Dresden, Germany.
13
Department of Medicine I, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians-University, Munich, Germany.

Abstract

INTRODUCTION:

Peripartum cardiomyopathy (PPCM) is a rare cardiomyopathy characterized by an acute reduction in left ventricular ejection fraction (LVEF). Sudden deaths during the course of PPCM are reported to be elevated, the underlying mechanisms remains unknown. The aim of the present multi-centre study was to evaluate the arrhythmia burden in a multi-centre approach in patients with PPCM using a wearable cardioverter/defibrillator (WCD).

METHODS AND RESULTS:

Forty-nine patients from 16 German centres with newly diagnosed PPCM and LVEF ≤35% receiving a WCD were included in this retrospective analysis. Mean follow-up was 15 ± 10 months. At diagnosis, mean age was 33 ± 5 years, parity was 2.1 ± 1.6, LVEF was 21 ± 7%, NYHA functional class was 3.4 ± 0.7. Mean wear time was 120 ± 106 days, mean wear time per day was 21.4 ± 3.3 h. Six (12%) patients presented eight ventricular tachyarrhythmias during WCD period: five episodes of VF, two sustained ventricular tachycardia (VT) and one non-sustained VT occurred.

CONCLUSION:

This multicentre study underpins the elevated risk for ventricular tachyarrhythmias in patients with newly diagnosed PPCM and reduced LVEF. A WCD should be considered for 3-6 months in these patients to prevent sudden cardiac death from ventricular tachyarrhythmias.

KEYWORDS:

Peripartum cardiomyopathy; Sudden cardiac death; Ventricular tachyarrhythmia; Wearable cardioverter/defibrillator

PMID:
28275862
PMCID:
PMC5529484
DOI:
10.1007/s00392-017-1090-5
[Indexed for MEDLINE]
Free PMC Article

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