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Leuk Res Rep. 2017 Jan 24;7:20-22. doi: 10.1016/j.lrr.2017.01.001. eCollection 2017.

A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia.

Author information

1
Department of Internal Medicine, George Washington U niversity School of Medicine and Health Sciences, Washington, DC, United States of America.
2
Department of Pathology, George Washington University Medical Faculty Associates, Washington, DC, United States of America.
3
Department of Hematology and Oncology, George Washington University Medical Faculty Associates, 2150 Pennsylvania Ave NW, Washington, DC 20037, United States of America.

Abstract

The V600 BRAF mutation has been described as a key mutation in the pathogenesis of classical hairy cell leukemia (c-HCL) cases without expression of a mutant immunoglobulin heavy chain (IgHV). Here we present a rare case of c-HCL with neither V600 BRAF mutation nor the aforementioned IgHV variant successfully treated with cladribine and review the current literature on its use in women of childbearing age/pregnancy.

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