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Electrolyte Blood Press. 2016 Dec;14(2):21-26. doi: 10.5049/EBP.2016.14.2.21. Epub 2016 Dec 31.

Genetic Variations of Tyrosine Hydroxylase in the Pathogenesis of Hypertension.

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Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.


One of the major pathophysiological features of primary hypertension is an inappropriate activation of the sympathetic nervous system, which is mediated by excessive synthesis and secretion of catecholamine into the blood. Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine, has been highlighted because genetic variations of TH could alter the activity of the sympathetic nervous system activity and subsequently contribute to the pathogenesis of hypertension. Here, we discuss the role of TH as a regulator of sympathetic activity and review several studies that investigated the relationship between genetic variations of TH and hypertension.


Hypertension; Single nucleotide polymorphism; Tyrosine hydroxylase

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