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Psychiatr Genet. 2017 Jun;27(3):116-119. doi: 10.1097/YPG.0000000000000170.

L-Methylfolate supplementation in a child with autism and methyltetrahydrofolate reductase, enzyme gene C677TT allele.

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Department of Pediatrics, University of Louisville School of Medicine, University of Louisville Autism Center, Louisville, Kentucky, USA.


Errors in folate metabolism may play a role in the pathology of autism spectrum disorders because of increased vulnerability to oxidative stress. We report a case where L-methylfolate supplementation improved symptoms of aggression and disruptive behavior in a child with autism who tested positive for the C677TT allele of the methyltetrahydrofolate reductase enzyme gene. To our knowledge, this is the first report of L-methylfolate administration in this situation. Further controlled studies of L-methylfolate in this population are warranted.

[Indexed for MEDLINE]

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