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J Immunol Res. 2017;2017:4915950. doi: 10.1155/2017/4915950. Epub 2017 Feb 8.

TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin.

Author information

1
Inserm, U 1183, Institute for Regenerative Medicine and Biotherapies, CHU Saint Eloi, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France; University of Montpellier, Boulevard Henri IV, 34090 Montpellier, France.
2
Inserm UMRs 1097, Aix-Marseille University, Marseille, France; Rheumatology Department, APHM, Marseille, France.
3
Inserm UMRs 1097, Aix-Marseille University, Marseille, France.
4
Inserm, U1051, University Hospital Saint Eloi, Institute for Neurosciences of Montpellier, Montpellier, France.
5
Inserm, U 1183, Institute for Regenerative Medicine and Biotherapies, CHU Saint Eloi, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France; University of Montpellier, Boulevard Henri IV, 34090 Montpellier, France; Department of Clinical Genetics, University Hospital of Montpellier, Montpellier, France.
6
Aix-Marseille University, CNRS, EFS, ADES UMR 7268, 13916 Marseille, France.
7
University of Montpellier, Boulevard Henri IV, 34090 Montpellier, France; Laboratoire d'Immunogénétique Moléculaire, UPR 1142 CNRS, Institute of Human Genetics, Montpellier, France.
8
Inserm, U 1183, Institute for Regenerative Medicine and Biotherapies, CHU Saint Eloi, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France; University of Montpellier, Boulevard Henri IV, 34090 Montpellier, France; Department of Molecular Genetics, University Hospital of Montpellier, France.
9
Aix-Marseille University, CNRS, Centrale Marseille, I2M, UMR 7373, 13453 Marseille, France.
10
CNRS UMR 5235, Université de Montpellier, Montpellier, France.
11
Inserm, U 1183, Institute for Regenerative Medicine and Biotherapies, CHU Saint Eloi, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France; University of Montpellier, Boulevard Henri IV, 34090 Montpellier, France; Clinical Department for Osteoarticular Diseases and Biotherapy, University Hospital Lapeyronie, 34295 Montpellier, France.
12
Laboratory of Human Genome and Multifactorial Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia.

Abstract

Polymorphisms have been identified in the Xq28 locus as risk loci for rheumatoid arthritis (RA). Here, we investigated the association between three polymorphisms in the Xq28 region containing TMEM187 and IRAK1 (rs13397, rs1059703, and rs1059702) in two unstudied populations: Tunisian and French. The rs13397 G and rs1059703 T major alleles were significantly increased in RA patients (n = 408) compared with age-matched controls (n = 471) in both Tunisian and French women. These results were confirmed by a meta-analysis replication study including two independent Greek and Korean cohorts. The rs1059702 C major allele was significantly associated with RA, only with French women. In the French population, the GTC haplotype displayed a protective effect against RA, while the ATC, GCC, and GTT haplotypes conferred significant risk for RA. No association for these haplotypes was found in the Tunisian population. Our results replicated for the first time the association of the three Xq28 polymorphisms with RA risk in Tunisian and French populations and suggested that RA susceptibility is associated with TMEM187-IRAK1 polymorphisms in women. Our data further support the involvement of X chromosome in RA susceptibility and evidence ethnicities differences that might be explained by differences in the frequencies of SE HLA-DRB1 alleles between both populations.

PMID:
28271077
PMCID:
PMC5320318
DOI:
10.1155/2017/4915950
[Indexed for MEDLINE]
Free PMC Article

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