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Biomed Opt Express. 2017 Jan 24;8(2):1056-1082. doi: 10.1364/BOE.8.001056. eCollection 2017 Feb 1.

Optical coherence tomography based angiography [Invited].

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1
Department of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, WA 98195, USA; Department of Ophthalmology, University of Washington, 325 9th Ave, Seattle, WA 98104, USA.

Abstract

Optical coherence tomography (OCT)-based angiography (OCTA) provides in vivo, three-dimensional vascular information by the use of flowing red blood cells as intrinsic contrast agents, enabling the visualization of functional vessel networks within microcirculatory tissue beds non-invasively, without a need of dye injection. Because of these attributes, OCTA has been rapidly translated to clinical ophthalmology within a short period of time in the development. Various OCTA algorithms have been developed to detect the functional micro-vasculatures in vivo by utilizing different components of OCT signals, including phase-signal-based OCTA, intensity-signal-based OCTA and complex-signal-based OCTA. All these algorithms have shown, in one way or another, their clinical values in revealing micro-vasculatures in biological tissues in vivo, identifying abnormal vascular networks or vessel impairment zones in retinal and skin pathologies, detecting vessel patterns and angiogenesis in eyes with age-related macular degeneration and in skin and brain with tumors, and monitoring responses to hypoxia in the brain tissue. The purpose of this paper is to provide a technical oriented overview of the OCTA developments and their potential pre-clinical and clinical applications, and to shed some lights on its future perspectives. Because of its clinical translation to ophthalmology, this review intentionally places a slightly more weight on ophthalmic OCT angiography.

KEYWORDS:

(110.4500) Optical coherence tomography; (170.2655) Functional monitoring and imaging; (170.3880) Medical and biological imaging

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