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Mol Brain. 2017 Mar 7;10(1):9. doi: 10.1186/s13041-017-0289-8.

Molecules in pain and sex: a developing story.

Author information

1
Program in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, ON, Canada.
2
Department of Physiology, University of Toronto, Toronto, ON, Canada.
3
University of Toronto Centre for the Study of Pain, Toronto, ON, Canada.
4
Developmental Neurosciences Programme, UCL Great Ormond Street Institute of Child Health, London, UK.
5
Program in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, ON, Canada. michael.salter@sickkids.ca.
6
Department of Physiology, University of Toronto, Toronto, ON, Canada. michael.salter@sickkids.ca.
7
University of Toronto Centre for the Study of Pain, Toronto, ON, Canada. michael.salter@sickkids.ca.

Abstract

Microglia are dynamic immune cells with diverse roles in maintaining homeostasis of the central nervous system. Dysregulation of microglia has been critically implicated in the genesis of neuropathic pain. Peripheral nerve injury, a common cause of neuropathic pain, engages microglia-neuronal signalling which causes disinhibition and facilitated excitation of spinal nociceptive pathways. However, recent literature indicates that the role of microglia in neuropathic pain is sexually dimorphic, and that female pain processing appears to be independent of microglia, depending rather on T cells. Despite this sex difference, pain signalling in the spinal cord converges downstream of microglia, as NMDAR-mediated facilitated excitation in pain transmitting neurons is consistent between males and females. Determining whether pain signalling is sexually dimorphic in humans and, further, addressing the sex bias in pain research will increase the translational relevance of preclinical findings and advance our understanding of chronic pain in women.

KEYWORDS:

Microglia; Neuropathic Pain; Sex differences; Spinal Cord; T cells

PMID:
28270169
PMCID:
PMC5341415
DOI:
10.1186/s13041-017-0289-8
[Indexed for MEDLINE]
Free PMC Article

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