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AMIA Annu Symp Proc. 2017 Feb 10;2016:1832-1839. eCollection 2016.

Development of a Novel Markov Chain Model for the Prediction of Head and Neck Squamous Cell Carcinoma Dissemination.

Author information

1
Department of Biomedical Informatics and Medical Education.
2
Department of Otolaryngology-Head and Neck Surgery.
3
Medical Scientist Training Program.
4
Department of Radiation Oncology.
5
Department of Biological Structure University of Washington, Seattle, WA.
6
Department of Biomedical Informatics and Medical Education; Department of Otolaryngology-Head and Neck Surgery.

Abstract

Prediction of microscopic tumor spread to regional lymph nodes can assist in radiation planning for cancer treatment. However, it is still challenging to predict tumor spread. In this paper, we present a unique approach to modeling how tumor cells disseminate to form regional metastases. This involves leveraging well established knowledge resources and commonly held notions of how cancer spreads. Using patient data, we utilized our approach to create a model of metastasis for the subset of head and neck squamous cell carcinoma that arises in the mucosa of the lateral tongue. The model was created using a training set extracted from the clinical records of 50 patients with tumors of this type who presented to the University of Washington head and tumor board over a three and half year period. The test sets consist of four case series drawn from the literature.

PMID:
28269942
PMCID:
PMC5333213
[Indexed for MEDLINE]
Free PMC Article

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