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J Cell Physiol. 2018 Feb;233(2):811-817. doi: 10.1002/jcp.25897. Epub 2017 May 3.

Role of Wnt/β-catenin signaling regulatory microRNAs in the pathogenesis of colorectal cancer.

Author information

1
Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2
Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3
Cancer Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4
Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
5
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
6
Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. In more than 90% of all CRC patients, the master oncogenic Ras-Wnt signaling axis is over-activated. MicroRNAs (miRNAs) are potential novel diagnostic and prognostic biomarkers as well as therapeutic targets for several cancers including lung, breast, gastric, and colorectal cancers. Oncogenic or tumor suppressor miRNAs modulate tumor cells proliferation, cell cycle progression, angiogenesis, invasion, and metastasis through regulating oncogenic pathways including Wnt/β-catenin signaling. This review summarizes the current knowledge about the role of Wnt/β-catenin signaling regulatory miRNAs in the pathogenesis of colorectal cancer for a better understanding and hence a better management of this disease.

KEYWORDS:

Wnt/β-catenin signaling; colorectal cancer; microRNA

PMID:
28266708
DOI:
10.1002/jcp.25897
[Indexed for MEDLINE]

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