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Endocr Relat Cancer. 2017 Apr;24(4):C5-C8. doi: 10.1530/ERC-17-0004.

From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal.

Author information

1
Department of Pathology and Endocrine Oncology Site GroupPrincess Margaret Cancer Centre, University Health Network, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada sylvia.asa@uhn.ca Jacqueline.trouillas@univ-lyon1.fr.
2
Department of PathologyUppsala University Hospital, Uppsala, Sweden.
3
Service of Endocrinology and Reproductive DiseasesBicêtre Hospital, Paris, France.
4
Department of MedicineUniversity of Louvain, Mont-sur-Meuse, Belgium.
5
Department of Anatomical PathologySt Vincent's Hospital, Sydney, Australia.
6
Department of Medicine and Endocrine Oncology Site GroupPrincess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, Ontario, Canada.
7
Department of EndocrinologyUniversity of Oxford, Oxford, UK.
8
Research Institute for Pituitary DiseaseSouthern Tohoku General Hospital, Fukushima, Japan.
9
Department of PathologyToranomon Hospital, Tokyo, Japan.
10
Department of EndocrinologyQueen Elizabeth Hospital, University of Birmingham, Birmingham, UK.
11
Division of EndocrinologyQueen Mary Hospital, Barts and the London School of Medicine, London, UK.
12
Department of NeurosurgeryHarvard Medical School, Brigham & Women's Hospital, Boston, Massachusetts, USA.
13
Departments of Pathology and Neurological SurgeryUniversity of Virginia, Charlottesville, Virginia, USA.
14
Department of NeurosurgeryRoyal Melbourne Hospital, The University of Melbourne, Melbourne, Australia.
15
Department of NeurosurgeryUT MD Anderson Cancer Center, Houston, Texas, USA.
16
Department of Pathology and Endocrine Oncology Site GroupPrincess Margaret Cancer Centre, University Health Network, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
17
Department of NeurosurgeryToranomon Hospital, Tokyo, Japan.
18
Department of EndocrinologyGroupement Hospitalier EST, Hospices Civils de Lyon, University of Lyon, Lyon, France.
19
Department of NeuropathologyImperial College, London, UK.
20
Institute of Neuropathology of the University of HamburgHamburg, Germany.
21
Department of NeurosurgeryHospital Pablo Tobon Uribe, Medellin, Colombia.
22
Department of PathologyGroupement Hospitalier EST, Hospices Civils de Lyon, University of Lyon, Lyon, France.
23
Department of PathologyHôpital Foch, Suresnes, France.
24
INSERM U1052Cancer Research Center of Lyon, University of Lyon, Lyon, France.
25
Faculty of Medicine Lyon-EstUniversity of Lyon, Lyon, France sylvia.asa@uhn.ca Jacqueline.trouillas@univ-lyon1.fr.

Abstract

The classification of neoplasms of adenohypophysial cells is misleading because of the simplistic distinction between adenoma and carcinoma, based solely on metastatic spread and the poor reproducibility and predictive value of the definition of atypical adenomas based on the detection of mitoses or expression of Ki-67 or p53. In addition, the current classification of neoplasms of the anterior pituitary does not accurately reflect the clinical spectrum of behavior. Invasion and regrowth of proliferative lesions and persistence of hormone hypersecretion cause significant morbidity and mortality. We propose a new terminology, pituitary neuroendocrine tumor (PitNET), which is consistent with that used for other neuroendocrine neoplasms and which recognizes the highly variable impact of these tumors on patients.

KEYWORDS:

nomenclature; pituitary tumors

PMID:
28264912
DOI:
10.1530/ERC-17-0004
[Indexed for MEDLINE]

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