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Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02632-16. doi: 10.1128/AAC.02632-16. Print 2017 May.

MCR-1.6, a New MCR Variant Carried by an IncP Plasmid in a Colistin-Resistant Salmonella enterica Serovar Typhimurium Isolate from a Healthy Individual.

Lu X1, Hu Y2, Luo M3, Zhou H1, Wang X1,4, Du Y1, Li Z1, Xu J4, Zhu B5, Xu X6, Kan B7.

Author information

1
State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.
2
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
3
Yulin Center for Disease Control and Prevention, Guangxi, China.
4
School of Food and Chemical Engineering, Beijing Technology and Business University, Beijing, China.
5
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China zhubaoli@im.ac.cn xxb72@sina.com kanbiao@icdc.cn.
6
Department of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China zhubaoli@im.ac.cn xxb72@sina.com kanbiao@icdc.cn.
7
State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China zhubaoli@im.ac.cn xxb72@sina.com kanbiao@icdc.cn.

Abstract

In this study, we report a novel mcr-1 gene variant, named mcr-1.6, carried by an IncP plasmid in a colistin-resistant Salmonella enterica serovar Typhimurium isolate from a healthy person. Compared with mcr-1, the mcr-1.6 gene contains two single-nucleotide polymorphisms, one of which results in an arginine to histidine variation (Arg536→His). The plasmid carrying the mcr-1.6 gene was designated pMCR1.6_P053 and is similar to a recently discovered mcr-1-bearing plasmid found in Klebsiella pneumoniae.

KEYWORDS:

IncP plasmid; MCR-1.6; Salmonella enterica serovar Typhimurium; colistin resistance

PMID:
28264851
PMCID:
PMC5404552
DOI:
10.1128/AAC.02632-16
[Indexed for MEDLINE]
Free PMC Article

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