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JAMA Neurol. 2017 May 1;74(5):591-596. doi: 10.1001/jamaneurol.2016.6159.

Precipitous Deterioration of Motor Function, Cognition, and Behavior.

Author information

1
Department of Neurology, La Paz University Hospital, Madrid, Spain2Memory and Aging Center, University of California, San Francisco, San Francisco.
2
Memory and Aging Center, University of California, San Francisco, San Francisco.
3
Memory and Aging Center, University of California, San Francisco, San Francisco3Department of Neurology, Tanz Centre, University of Toronto, Toronto, Canada.
4
Departments of Psychiatry & Biobehavioral Sciences and Neurology, University of California, Los Angeles.
5
Department of Neurology, Division of Movement Disorders, University of California, San Francisco, San Francisco.
6
Department of Pathology, University of California San Francisco and Pathology Service, Veterans Affairs Medical Center, San Francisco.
7
Memory and Aging Center, University of California, San Francisco, San Francisco7Department of Pathology, University of California San Francisco, San Francisco.
8
Department of Pathology, University of California San Francisco, San Francisco.

Abstract

A 72-year-old woman developed new-onset depression, sustained an unexplained fall, and started walking cautiously. After 1 year, her depression resolved but she developed a dry cough. One year later, she experienced a more rapid decline in her gait with parkinsonism, visual difficulties with restricted vertical gaze, slowed horizontal and vertical saccades, dysphagia, apathy, and progressive cognitive decline, which led to her death 2 years later. The differential diagnosis, neuroimaging, and pathological findings are discussed, as well as their public health implications.

PMID:
28264087
PMCID:
PMC5600817
DOI:
10.1001/jamaneurol.2016.6159
[Indexed for MEDLINE]
Free PMC Article

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