Format

Send to

Choose Destination
Alzheimers Dement. 2017 Sep;13(9):1013-1023. doi: 10.1016/j.jalz.2017.01.019. Epub 2017 Mar 3.

The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: A European Alzheimer's Disease Consortium study.

Author information

1
Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy.
2
Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.
3
IRCCS Istituto Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy.
4
IXICO Plc, London, UK.
5
INFN, Genova, Italy.
6
McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; True Positive Medical Devices Inc., Quebec City, Quebec, Canada.
7
True Positive Medical Devices Inc., Quebec City, Quebec, Canada.
8
Advanced Clinical Imaging Technology (HC CMEA SUI DI BM PI), Siemens Healthcare AG, Lausanne, Switzerland; Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland; LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
9
Alzheimer Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain.
10
University Hospitals and University of Geneva, Geneva, Switzerland.
11
Alzheimer's and Other Cognitive Disorder Unit, Hospital Clinic, Barcelona, Spain.
12
GIGA-CRC In vivo Imaging and Memory Clinic, University of Liège, Liège, Belgium.
13
First Department of Neurology, Eginition Hospital Kapodistrian University, Medical School of Athens, Athens, Greece.
14
Department of Psychology, Dokuz Eylül University, Izmir, Turkey; Izmir International Biomedicine and Genome Center, Dokuz Eylul University, Izmir, Turkey.
15
Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium; Memory Clinic and Department of Neurology, Hospital Network Antwerp (ZNA) Hoge Beuken and Middelheim, Antwerp, Belgium.
16
Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
17
Radiology and Medical Imagery, Elias University Clinical Hospital, Bucharest, Romania.
18
Department of Neurology, Centre for Cognitive Impairments, University Medical Center Ljubljana, Ljubljana, Slovenia.
19
Mercer's Institute for Successful Ageing, St. James's Hospital, Dublin, Ireland.
20
Institute of Neurology, CCS, Belgrade, Serbia.
21
Department of Geriatrics-Gerontology and Old Age Psychiatry, Elias University Clinic, Bucharest, Romania.
22
Istituto di Gerontologia e Geriatria, Università degli Studi di Perugia, Perugia, Italy.
23
Medical Imaging Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
24
Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium.
25
Clinical Neurology (DINOGMI), University of Genoa and IRCCS AOU San Martino-IST, Genoa, Italy.
26
3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
27
Clinical Neurology (DINOGMI), University of Genoa and IRCCS AOU San Martino-IST, Genoa, Italy; Memory Clinic and LANVIE-Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland.
28
Neurology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
29
Carol Davila University of Medicine, Bucharest, Romania; Ana Aslan Intl Foundation-Memory Clinic, Bucharest, Romania.
30
Institute of Neurology, CCS, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
31
Clinical Institute of Radiology, University Medical Center Ljubljana, Slovenia.
32
Izmir International Biomedicine and Genome Center, Dokuz Eylul University, Izmir, Turkey; Department of Neurology, Dokuz Eylül University, Izmir, Turkey; Brain Dynamics Multidisciplinary Research Center, Dokuz Eylül University, Izmir, Turkey.
33
Department of Internal Medicine, Rehabilitation and Geriatrics, University Hospitals and University of Geneva, Geneva, Switzerland.
34
Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy; Memory Clinic and LANVIE-Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland. Electronic address: gfrisoni@fatebenefratelli.eu.

Abstract

INTRODUCTION:

Hippocampal volume is a core biomarker of Alzheimer's disease (AD). However, its contribution over the standard diagnostic workup is unclear.

METHODS:

Three hundred fifty-six patients, under clinical evaluation for cognitive impairment, with suspected AD and Mini-Mental State Examination ≥20, were recruited across 17 European memory clinics. After the traditional diagnostic workup, diagnostic confidence of AD pathology (DCAD) was estimated by the physicians in charge. The latter were provided with the results of automated hippocampal volumetry in standardized format and DCAD was reassessed.

RESULTS:

An increment of one interquartile range in hippocampal volume was associated with a mean change of DCAD of -8.0% (95% credible interval: [-11.5, -5.0]). Automated hippocampal volumetry showed a statistically significant impact on DCAD beyond the contributions of neuropsychology, 18F-fluorodeoxyglucose positron emission tomography/single-photon emission computed tomography, and cerebrospinal fluid markers (-8.5, CrI: [-11.5, -5.6]; -14.1, CrI: [-19.3, -8.8]; -10.6, CrI: [-14.6, -6.1], respectively).

DISCUSSION:

There is a measurable effect of hippocampal volume on DCAD even when used on top of the traditional diagnostic workup.

KEYWORDS:

Alzheimer's disease; Biomarkers; Diagnostic confidence of AD; Hippocampal volume; Medial temporal lobe atrophy

PMID:
28263741
DOI:
10.1016/j.jalz.2017.01.019
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center