Format

Send to

Choose Destination
Nat Med. 2017 May;23(5):548-550. doi: 10.1038/nm.4302. Epub 2017 Mar 6.

Diagnosis of Zika virus infection on a nanotechnology platform.

Author information

1
Nirmidas Biotech, Palo Alto, California, USA.
2
Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
3
Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA.
4
Department of Materials Science and Engineering, South University of Science and Technology of China, Shenzhen, China.
5
Medical Research Institute, Colombo, Sri Lanka.
6
Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
7
Department of Chemistry, Stanford University, Stanford, California, USA.

Abstract

We developed a multiplexed assay on a plasmonic-gold platform for measuring IgG and IgA antibodies and IgG avidity against both Zika virus (ZIKV) and dengue virus (DENV) infections. In contrast to IgM cross-reactivity, IgG and IgA antibodies against ZIKV nonstructural protein 1 (NS1) antigen were specific to ZIKV infection, and IgG avidity revealed recent ZIKV infection and past DENV-2 infection in patients in dengue-endemic regions. This assay could enable specific diagnosis of ZIKV infection over other flaviviral infections.

PMID:
28263312
DOI:
10.1038/nm.4302
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center