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Sci Rep. 2017 Mar 6;7:43395. doi: 10.1038/srep43395.

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses.

Author information

1
Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
2
Gilead Sciences, Inc. Foster City, California, USA.

Abstract

GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection. It has been administered under compassionate use to two Ebola patients, both of whom survived, and is currently in Phase 2 clinical development for treatment of Ebola virus disease. Here we report the antiviral activities of GS-5734 and the parent nucleoside analog across multiple virus families, providing evidence to support new indications for this compound against human viruses of significant public health concern.

PMID:
28262699
PMCID:
PMC5338263
DOI:
10.1038/srep43395
[Indexed for MEDLINE]
Free PMC Article

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