Format

Send to

Choose Destination
FEBS J. 2017 Mar;284(5):708-710. doi: 10.1111/febs.14031.

There is something about BOK we just don't get yet.

Author information

1
Division of Developmental Immunology, BIOCENTER, Medical University of Innsbruck, Innsbruck, Austria.
2
Tyrolean Cancer Research Institute, Innsbruck, Austria.

Abstract

Fernández-Marrero and colleagues show in their work that the proapoptotic BCL-2 family member BOK can form large, stable pores in artificial liposomes. This can be enhanced by the proapoptotic protein cBID and is unaffected by the antiapoptotic BCL-XL . Although BOK can bind to isolated mitochondria, it is unable to cause cytochrome c release even with the help of cBID.

PMID:
28262002
DOI:
10.1111/febs.14031
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center