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Magn Reson Med. 2018 Jan;79(1):407-415. doi: 10.1002/mrm.26660. Epub 2017 Mar 5.

Orthogonally combined motion- and diffusion-sensitized driven equilibrium (OC-MDSDE) preparation for vessel signal suppression in 3D turbo spin echo imaging of peripheral nerves in the extremities.

Author information

1
Department of Diagnostic and Interventional Radiology, Technische Universität München, Munich, Germany.
2
Department of Neuroradiology, Technische Universität München, Munich, Germany.
3
Philips Healthcare, Hamburg, Germany.
4
Philips Research Laboratory, Hamburg, Germany.
5
Institute of Medical Engineering, Technische Universität München, Garching, Germany.

Abstract

PURPOSE:

To design a preparation module for vessel signal suppression in MR neurography of the extremities, which causes minimal attenuation of nerve signal and is highly insensitive to eddy currents and motion.

METHODS:

The orthogonally combined motion- and diffusion-sensitized driven equilibrium (OC-MDSDE) preparation was proposed, based on the improved motion- and diffusion-sensitized driven equilibrium methods (iMSDE and FC-DSDE, respectively), with specific gradient design and orientation. OC-MDSDE was desensitized against eddy currents using appropriately designed gradient prepulses. The motion sensitivity and vessel signal suppression capability of OC-MDSDE and its components were assessed in vivo in the knee using 3D turbo spin echo (TSE). Nerve-to-vessel signal ratios were measured for iMSDE and OC-MDSDE in 7 subjects.

RESULTS:

iMSDE was shown to be highly sensitive to motion with increasing flow sensitization. FC-DSDE showed robustness against motion, but resulted in strong nerve signal loss with diffusion gradients oriented parallel to the nerve. OC-MDSDE showed superior vessel suppression compared to iMSDE and FC-DSDE and maintained high nerve signal. Mean nerve-to-vessel signal ratios in 7 subjects were 0.40 ± 0.17 for iMSDE and 0.63 ± 0.37 for OC-MDSDE.

CONCLUSION:

OC-MDSDE combined with 3D TSE in the extremities allows high-near-isotropic-resolution imaging of peripheral nerves with reduced vessel contamination and high nerve signal. Magn Reson Med 79:407-415, 2018. © 2017 Wiley Periodicals, Inc.

KEYWORDS:

3D turbo spin echo (TSE); black blood imaging; magnetic resonance neurography; motion-sensitized diffusion preparation (MSDE); peripheral nerves MRI

PMID:
28261861
DOI:
10.1002/mrm.26660
[Indexed for MEDLINE]

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