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Front Immunol. 2017 Feb 16;8:56. doi: 10.3389/fimmu.2017.00056. eCollection 2017.

Potential Value of miR-221/222 as Diagnostic, Prognostic, and Therapeutic Biomarkers for Diseases.

Author information

1
Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China; Shanghai University of Medicine & Health, Shanghai Sixth People's Hospital East Campus, Shanghai, China.
2
School of Pharmacy, Shanghai Jiao Tong University , Shanghai , China.
3
Department of Neurology, Jinshan Hospital, Fudan University , Shanghai , China.
4
Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai , China.

Abstract

microRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by base pairing with their target messenger RNAs. Dysregulation of miRNAs is involved in the pathological initiation and progression of many human diseases. miR-221 and miR-222 (miR-221/222) are two highly homologous miRNAs, and they are significantly overexpressed in several types of human diseases. Silencing miR-221/222 could represent a promising approach for therapeutic studies. In the present review, we will describe the potential value of miR-221/222 as diagnostic, prognostic, and therapeutic biomarkers in various diseases including cancer and inflammatory diseases.

KEYWORDS:

biomarker; diagnosis; diseases; miR-221/222; microRNAs; prognosis; therapy

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