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Front Endocrinol (Lausanne). 2017 Feb 16;8:29. doi: 10.3389/fendo.2017.00029. eCollection 2017.

Systemic Regulators of Skeletal Muscle Regeneration in Obesity.

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Division of Plastic Surgery, Brigham and Women's Hospital , Boston, MA , USA.


Skeletal muscle maintenance is a dynamic process and undergoes constant repair and regeneration. However, skeletal muscle regenerative capacity declines in obesity. In this review, we focus on obesity-associated changes in inflammation, metabolism, and impaired insulin signaling, which are pathologically dysregulated and ultimately result in a loss of muscle mass and function. In addition, we examine the relationships between skeletal muscle, liver, and visceral adipose tissue in an obese state.


inflammation; insulin; metabolism; obesity; skeletal muscle

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