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Curr Opin Chem Biol. 2017 Jun;38:36-44. doi: 10.1016/j.cbpa.2017.02.005. Epub 2017 Mar 2.

Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era.

Author information

1
Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61822, USA.
2
Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61822, USA. Electronic address: vddonk@illinois.edu.

Abstract

In the past 15 years, the cost of sequencing a genome has plummeted. Consequently, the number of sequenced bacterial genomes has exponentially increased, and methods for natural product discovery have evolved rapidly to take advantage of the wealth of genomic data. This review highlights applications of genome mining software to compare and organize large-scale data sets and methods for identifying unique biosynthetic pathways amongst the thousands of ribosomally synthesized and post-translationally modified peptide (RiPP) gene clusters. We also discuss a small number of the many RiPPs discovered in the years 2014-2016.

PMID:
28260651
PMCID:
PMC5474203
DOI:
10.1016/j.cbpa.2017.02.005
[Indexed for MEDLINE]
Free PMC Article

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