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Curr Opin Neurobiol. 2017 Apr;43:102-109. doi: 10.1016/j.conb.2017.02.004. Epub 2017 Mar 4.

Plasticity of hippocampal memories in humans.

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Department of Psychology, University of York, York YO10 5DD, UK. Electronic address:
Kavli Institute for Systems Neuroscience, Centre for Neural Computation, The Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, NTNU, Norwegian University of Science and Technology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.


The human hippocampus is a brain region that supports episodic and spatial memory. Recent experiments have drawn on animal research and computational modelling to reveal how the unique computations and representations of the hippocampus support episodic and spatial memory. Invasive electrophysiological recordings and non-invasive functional brain imaging have provided evidence for the rapid formation of hippocampal representations, as well as the ability of the hippocampus to both pattern-separate and pattern-complete input from the neocortex. Further, recent evidence has shown that hippocampal representations are in constant flux, undergoing a continual process of strengthening, weakening and altering. This research offers a glimpse into the highly plastic and flexible nature of the human hippocampal system in relation to episodic memory.

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