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Redox Biol. 2017 Aug;12:208-215. doi: 10.1016/j.redox.2017.02.012. Epub 2017 Feb 24.

Mitochondrial composition and function under the control of hypoxia.

Author information

1
Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.
2
Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany; Project Group Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology, 60596 Frankfurt, Germany. Electronic address: b.bruene@biochem.uni-frankfurt.de.

Abstract

Hypoxia triggers several mechanisms to adapt cells to a low oxygen environment. Mitochondria are major consumers of oxygen and a potential source of reactive oxygen species (ROS). In response to hypoxia they exchange or modify distinct subunits of the respiratory chain and adjust their metabolism, especially lowering the citric acid cycle. Intermediates of the citric acid cycle participate in regulating hypoxia inducible factors (HIF), the key mediators of adaptation to hypoxia. Here we summarize how hypoxia conditions mitochondria with consequences for ROS-production and the HIF-pathway.

KEYWORDS:

HIF; Hypoxia; Mitochondria; ROS; Respiratory chain

PMID:
28259101
PMCID:
PMC5333533
DOI:
10.1016/j.redox.2017.02.012
[Indexed for MEDLINE]
Free PMC Article

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