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J Autism Dev Disord. 2017 May;47(5):1490-1495. doi: 10.1007/s10803-017-3050-3.

An Italian Prospective Experience on the Association Between Congenital Cytomegalovirus Infection and Autistic Spectrum Disorder.

Author information

1
Neonatal Immunology Laboratory, Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy. lab.immunoneo@smatteo.pv.it.
2
Neonatal Unit and Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia Piazzale Golgi 1, 27100, Pavia, Italy.
3
Unit of Child Neurology and Psychiatry, IRCCS C. Mondino National Neurological Institute, 27100, Pavia, Italy.
4
Neonatal Immunology Laboratory, Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy.
5
Department of Internal Medicine and Therapeutics, University of Pavia, 27100, Pavia, Italy.

Abstract

The aim of this retrospective study, with prospective data collection, was to correlate congenital cytomegalovirus (CMV) infection with autism spectrum disorder (ASD) and to define its prevalence. Seventy proven congenitally-infected infants, born between 2007 and 2012, were referred to our centre for CMV diagnosis and follow-up, which consisted of a consolidated protocol allowing an early evaluation of autism. We considered four children 2-year old, two of whom, at the age of 3, were diagnosed with ASD demonstrating a 2-3 fold higher prevalence (2.86%), than that in general Italian population (0.66-1.36%).Our protocol enabled us to make the earliest diagnosis and highlight the role of the virus among other causes of autism, which may be a long term sequela of congenital CMV.

KEYWORDS:

Autism spectrum disorder; Congenital Cytomegalovirus; Neonate; Prevalence

PMID:
28258350
DOI:
10.1007/s10803-017-3050-3
[Indexed for MEDLINE]

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