Format

Send to

Choose Destination
Pharmacol Biochem Behav. 2018 Nov;174:23-32. doi: 10.1016/j.pbb.2017.02.006. Epub 2017 Feb 28.

Viral vector strategies for investigating midbrain dopamine circuits underlying motivated behaviors.

Author information

1
Department of Molecular and Cell Biology, University of California, Berkeley, 142 Life Science Addition #3200, CA 94720, USA.
2
Department of Molecular and Cell Biology, University of California, Berkeley, 142 Life Science Addition #3200, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, 142 Life Science Addition #3200, CA 94720, USA. Electronic address: lammel@berkeley.edu.

Abstract

Midbrain dopamine (DA) neurons have received significant attention in brain research because of their central role in reward processing and their dysfunction in neuropsychiatric disorders such as Parkinson's disease, drug addiction, depression and schizophrenia. Until recently, it has been thought that DA neurons form a homogeneous population whose primary function is the computation of reward prediction errors. However, through the implementation of viral vector strategies, an unexpected complexity and diversity has been revealed at the anatomical, molecular and functional level. In this review, we discuss recent viral vector approaches that have been leveraged to dissect how different circuits involving distinct DA neuron subpopulations may contribute to the role of DA in reward- and aversion-related behaviors. We focus on studies that have used cell type- and projection-specific optogenetic manipulations, discuss the strengths and limitations of each approach, and critically examine emergent organizational principles that have led to a reclassification of midbrain DA neurons.

KEYWORDS:

Aversion; Dopamine; Mesocorticolimbic; Optogenetics; Reward; Ventral tegmental area

PMID:
28257849
DOI:
10.1016/j.pbb.2017.02.006

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center