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Molecules. 2017 Mar 2;22(3). pii: E387. doi: 10.3390/molecules22030387.

Pharmacological Activities and Synthesis of Esculetin and Its Derivatives: A Mini-Review.

Author information

1
Faculty of Pharmacy, Shaanxi University of Science & Technology, 6 Xuefu Road, Xi'an 710021, China. chengyuanliang@gmail.com.
2
Faculty of Pharmacy, Shaanxi University of Science & Technology, 6 Xuefu Road, Xi'an 710021, China. juweihui11521@sina.com.
3
Faculty of Pharmacy, Shaanxi University of Science & Technology, 6 Xuefu Road, Xi'an 710021, China. huabienaiqiao@sina.com.
4
Xi'an Taikomed Pharmaceutical technology Co., LTD, Xi'an 710077, China. techno8833@taikomed.com.
5
Faculty of Finance and Economics, Guangzhou Vocational College of Science and Technology, Guangzhou 510550, China. lvyuecheng@126.com.

Abstract

Esculetin, synonymous with 6,7-dihydroxycoumarin, is the main active ingredient of the traditional Chinese medicine Cortex Fraxini. The twig skin or trunk bark of Cortex Fraxini are used by herb doctors as a mild, bitter liver and gallbladder meridians' nontoxic drug as well as dietary supplement. Recently, with a variety of novel esculetin derivatives being reported, the molecular mechanism research as well as clinical application of Cortex Fraxini and esculetin are becoming more attractive. This mini-review will consolidate what is known about the biological activities, the mechanism of esculetin and its synthetic derivatives over the past decade in addition to providing a brief synopsis of the properties of esculetin.

KEYWORDS:

coumarin; esculetin; molecular mechanism; pharmacological activity; synthetic derivatives

PMID:
28257115
PMCID:
PMC6155195
DOI:
10.3390/molecules22030387
[Indexed for MEDLINE]
Free PMC Article

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