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J Mol Neurosci. 2017 Apr;61(4):590-602. doi: 10.1007/s12031-017-0900-6. Epub 2017 Mar 2.

Epigenetic Mistakes in Neurodevelopmental Disorders.

Author information

1
Division of Neuroscience, San Raffaele Hospital, Via Olgettina 58, 20132, Milan, Italy.
2
Division of Neuroscience, San Raffaele Hospital, Via Olgettina 58, 20132, Milan, Italy. sessa.alessandro@hsr.it.

Abstract

Epigenetics is the array of the chromatin modifications that customize in cell-, stage-, or condition-specific manner the information encloses in plain DNA molecules. Increasing evidences suggest the importance of epigenetic mechanisms for development and maintenance of central nervous system. In fact, a large number of newly discovered genetic causes of neurodevelopmental disorders such as intellectual disability, autism spectrum disorders, and many other syndromes are mutations within genes encoding for chromatin remodeling enzymes. Here, we review recent findings on the epigenetic origin of human diseases, with emphasis on disorders that affect development of the nervous system, and discuss novel therapeutic avenues that target epigenetic mechanisms.

KEYWORDS:

Epigenetics; Intellectual disability; Neurodevelopmental disorders

PMID:
28255957
DOI:
10.1007/s12031-017-0900-6
[Indexed for MEDLINE]

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