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Biol Trace Elem Res. 2017 Oct;179(2):195-202. doi: 10.1007/s12011-017-0982-6. Epub 2017 Mar 2.

Serum Selenium Levels and Cervical Cancer: Systematic Review and Meta-Analysis.

He D1,2, Wang Z1,2, Huang C1,2, Fang X1,2, Chen D3,4.

Author information

1
Department of Oncology, The Central Hospital of Enshi Autonomous of Prefecture, Enshi Clinical College of Wuhan University, Enshi, 445000, China.
2
Enshi Clinical College of Wuhan University, Enshi, China.
3
Department of Oncology, The Central Hospital of Enshi Autonomous of Prefecture, Enshi Clinical College of Wuhan University, Enshi, 445000, China. hdu1234@163.com.
4
Enshi Clinical College of Wuhan University, Enshi, China. hdu1234@163.com.

Abstract

Several studies have investigated the relationship between serum Se concentration and cervical cancer, but the results were inconsistent. Thus, we conducted a systematic review and meta-analysis to evaluate the association between serum selenium levels and cervical cancer. Twelve studies investigating the association by univariate analysis and five studies by multivariate analysis were identified after a systematic search of PubMed, Wanfang, CNKI, and SinoMed databases. Standard mean differences (SMD) or odds ratios (OR) with the corresponding 95% confidence intervals (CI) were pooled to compare the selenium levels between different groups. In univariate analysis, serum selenium levels in cervical cancer cases were significantly lower than in controls (SMD = -4.86, 95% CI -6.03-3.69). Subgroup analysis showed consistent results. In multivariate analysis, serum selenium levels in cervical cancer cases were also significantly lower than in controls (OR = 0.55, 95% CI 0.42-0.73). After treatment, the serum selenium levels increased significantly (SMD = 2.59, 95% CI 0.50-4.69). In conclusion, high serum selenium levels were associated with cervical cancer, and selenium exposure might be a protective factor for cervical cancer.

KEYWORDS:

Cervical cancer; Meta-analysis; Selenium; Serum

PMID:
28255860
DOI:
10.1007/s12011-017-0982-6
[Indexed for MEDLINE]

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