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Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):93-108.A. doi: 10.1016/j.bbcan.2017.02.005. Epub 2017 Feb 28.

Osteopontin splice variants and polymorphisms in cancer progression and prognosis.

Author information

1
Regeneration and Repair, Institute of Hepatology, Foundation for Liver Research, London, United Kingdom.
2
Instituto Nacional de Medicina Genómica, INMEGEN, Periférico Sur 4809, Ciudad de México 14610, México. Electronic address: seavendano@inmegen.gob.mx.
3
Instituto Nacional de Medicina Genómica, INMEGEN, Periférico Sur 4809, Ciudad de México 14610, México.
4
James L. Winkle College of Pharmacy, University of Cincinnati Academic Health Center, Cincinnati, OH, United States.
5
Regeneration and Repair, Institute of Hepatology, Foundation for Liver Research, London, United Kingdom; Division of Gastroenterology and Hepatology, Department of Medicine, Medical University of South Carolina, Charleston, SC., United States; Section of Gastroenterology, Ralph H Johnson Veteran Affairs Medical Center, Charleston, SC, United States. Electronic address: synw@musc.edu.

Abstract

Osteopontin (OPN) is an extracellular matrix protein that is overexpressed in various cancers and promotes oncogenic features including cell proliferation, survival, migration, and angiogenesis, among others. OPN can participate in the regulation of the tumor microenvironment, affecting both cancer and neighboring cells. Here, we review the roles of OPN splice variants (a, b, c) in cancer development, progression, and prognosis, and also discuss the identities of isoforms 4 and 5. We also discussed how single-nucleotide polymorphisms (SNPs) of the OPN gene are an additional factor influencing the level of OPN in individuals, modulating the risks of cancer development and outcome.

KEYWORDS:

Alternative splicing isoforms; Malignancy; Prognosis; Single nucleotide polymorphisms (SNPs); Spp1

PMID:
28254527
DOI:
10.1016/j.bbcan.2017.02.005
[Indexed for MEDLINE]

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