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Mol Cell Endocrinol. 2017 Nov 15;456:95-101. doi: 10.1016/j.mce.2017.02.043. Epub 2017 Feb 27.

The small RNA miR-375 - a pancreatic islet abundant miRNA with multiple roles in endocrine beta cell function.

Author information

1
Unit of Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, CRC, SUS Malmö, Malmö, Sweden. Electronic address: lena.eliasson@med.lu.se.

Abstract

The pathophysiology of diabetes is complex and recent research put focus on the pancreatic islets of Langerhans and the insulin-secreting beta cells as central in the development of the disease. MicroRNAs (miRNAs), the small non-coding RNAs regulating post-transcriptional gene expression, are significant regulators of beta cell function. One of the most abundant miRNAs in the islets is miR-375. This review focus on the role of miR-375 in beta cell function, including effects in development and differentiation, proliferation and regulation of insulin secretion. It also discusses the regulation of miR-375 expression, miR-375 as a potential circulating biomarker in type 1 and type 2 diabetes, and the need for the beta cell to keep expression of miR-375 within optimal levels. The summed picture of miR-375 is a miRNA with multiple functions with importance in the formation of beta cell identity, control of beta cell mass and regulation of insulin secretion.

KEYWORDS:

Beta cell; Diabetes; Differentiation; Insulin; Insulin secretion; Islet of langerhans; MicroRNA; Proliferation; miR-375

PMID:
28254488
DOI:
10.1016/j.mce.2017.02.043
[Indexed for MEDLINE]

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