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Trends Immunol. 2017 May;38(5):310-322. doi: 10.1016/j.it.2017.01.006. Epub 2017 Feb 20.

IL-17 Signaling: The Yin and the Yang.

Author information

1
Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
2
Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address: sarah.gaffen@pitt.edu.

Abstract

Interleukin (IL)-17 is the founding member of a novel family of inflammatory cytokines. While the proinflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL-17 signaling is associated with immunopathology, autoimmune disease, and cancer progression. In this review we discuss both the activators and the inhibitors of IL-17 signal transduction, and also the physiological implications of these events. We highlight the surprisingly diverse means by which these regulators control expression of IL-17-dependent inflammatory genes, as well as the major target cells that respond to IL-17 signaling.

PMID:
28254169
PMCID:
PMC5411326
DOI:
10.1016/j.it.2017.01.006
[Indexed for MEDLINE]
Free PMC Article

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