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Semin Nephrol. 1987 Sep;7(3):263-73.

Effect of potassium on renal acidification and acid-base homeostasis.

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Division of Nephrology, University of Michigan Medical School, Ann Arbor 48109-0364.


In summary, altered potassium homeostasis can modify bicarbonate reabsorption by the proximal tubule and alter acidification by the distal nephron both by affecting proton transport in a primary fashion and by modifying renal ammonia production. With physiologic variations in dietary K+ intake, these processes may serve to sustain concurrent potassium and acid-base homeostasis. However, with pathologic degrees of potassium depletion and hyperkalemia, metabolic alkalosis and acidosis, respectively, can result.

[Indexed for MEDLINE]

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