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Eur J Nutr. 2018 Jun;57(4):1333-1342. doi: 10.1007/s00394-017-1412-4. Epub 2017 Mar 1.

Coffee, tea, caffeine, and risk of hypertension: The Singapore Chinese Health Study.

Author information

1
Office of Clinical Sciences, Duke-NUS Medical School, Singapore, 169857, Singapore.
2
National Heart Center Singapore, Singapore, 169609, Singapore.
3
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, 117549, Singapore.
4
Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
5
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
6
Office of Clinical Sciences, Duke-NUS Medical School, Singapore, 169857, Singapore. woonpuay.koh@duke-nus.edu.sg.
7
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, 117549, Singapore. woonpuay.koh@duke-nus.edu.sg.

Abstract

PURPOSE:

The relationship between coffee and tea, and risk of hypertension remains controversial in Western populations. We investigated these associations in an Asian population.

METHODS:

The Singapore Chinese Health Study is a population-based prospective cohort that recruited 63,257 Chinese aged 45-74 years and residing in Singapore from 1993 to 1998. Information on consumption of coffee, tea, and other lifestyle factors was collected at baseline, and self-reported physician-diagnosed hypertension was assessed during two follow-up interviews (1999-2004, 2006-2010).

RESULTS:

We identified 13,658 cases of incident hypertension after average 9.5 years. Compared to those who drank one cup of coffee/day, the hazard ratios (HR) and 95% confidence intervals (CI) were 0.87 (0.83-0.91) for <weekly drinkers and 0.93 (0.86-1.00) for ≥3 cups/day drinkers. Compared to <weekly drinkers, daily drinkers of black or green tea had slight increase in risk, but these risk estimates were attenuated and became non-significant after adjustment for caffeine. After adjusting for coffee, there was a stepwise dose-response relationship between caffeine intake and hypertension risk; compared to the lowest intake (<50 mg/day), those in the highest intake (≥300 mg/day) had a 16% increase in risk; HR 1.16, 95% CI 1.04-1.31 (p trend = 0.02).

CONCLUSIONS:

Drinking coffee <1 cup/week or ≥3 cups/day had lower risk than drinking one cup/day. Caffeine may account for increased risk in daily tea drinkers and in those who drank one cup of coffee/day. The inverse U-shaped association with coffee suggests that at higher doses, other ingredients in coffee may offset the effect of caffeine and confer benefit on blood pressure.

KEYWORDS:

Caffeine; Coffee; Hypertension; Prospective study; Tea

PMID:
28251341
DOI:
10.1007/s00394-017-1412-4
[Indexed for MEDLINE]

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