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Gut Pathog. 2017 Feb 22;9:11. doi: 10.1186/s13099-017-0160-6. eCollection 2017.

Oral administration of Clostridium butyricum CGMCC0313-1 inhibits β-lactoglobulin-induced intestinal anaphylaxis in a mouse model of food allergy.

Author information

1
Department of Pediatrics, Xijing Hospital, the Fourth Military Medical University, Xi'an, 710032 China.
2
Department of Geratology, Xijing Hospital, the Fourth Military Medical University, Xi'an, 710032 China.
3
Respiratory Department, Shenzhen Children's Hospital, Shenzhen, 518036 China.

Abstract

BACKGROUND:

Probiotic bacteria can induce immune regulation or immune tolerance in patients with allergic diseases, but the underlying mechanisms are still unclear. There has been a growing interest in the use of beneficial bacteria for allergic diseases recently. This study aimed at exploring whether Clostridium butyricum CGMCC0313-1 (C. butyricum) can reduce β-lactoglobulin(BLG)-induced intestinal anaphylaxis in a murine model of food allergy.

METHODS:

The preventive and therapeutic effects of oral C. butyricum on anaphylactic symptoms induced via BLG in food allergy mice were investigated. Intestinal anaphylaxis, T helper (Th)-specific cytokines and transcription factors, secretory IgA (sIgA), CD4+ CD25+ Foxp3Treg cell and histopathological alterations were examined.

RESULTS:

Clostridium butyricum significantly ameliorated intestinal anaphylaxis symptoms in the food allergy mice. sIgA and CD4+ CD25+ Foxp3Treg cell were increased by oral C. butyricum. It also reversed the imbalance of Th1/Th2 andTh17/Treg.

CONCLUSIONS:

Clostridium butyricum reduces BLG-induced intestinal anaphylaxis in mice and might be an additional or supplementary therapy for food allergy.

KEYWORDS:

Clostridium butyricum; Food allergy; Mice; Probiotics; β-Lactoglobulin

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