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Evid Based Complement Alternat Med. 2017;2017:2103254. doi: 10.1155/2017/2103254. Epub 2017 Jan 5.

Pharmacological Basis for Use of Selaginella moellendorffii in Gouty Arthritis: Antihyperuricemic, Anti-Inflammatory, and Xanthine Oxidase Inhibition.

Author information

1
Key Laboratory of Ministry of Education on Traditional Chinese Medicine Resource and Compound Prescription and College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, China.
2
Key Laboratory of Ministry of Education on Traditional Chinese Medicine Resource and Compound Prescription and College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, China; Department of Pharmacy, Huanggang Hospital of Traditional Chinese Medicine, Huanggang 438000, China.
3
Key Laboratory of Ministry of Education on Traditional Chinese Medicine Resource and Compound Prescription and College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, China; State Key Laboratory of Dao-Di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.

Abstract

This study was aimed at evaluating the effects of Selaginella moellendorffii Hieron. (SM) on gouty arthritis and getting an insight of the possible mechanisms. HPLC method was developed for chemical analysis. The paw oedema, the neutrophil accumulation, inflammatory mediators, lipid peroxidation, and histopathological changes of the joints were analyzed in gouty arthritis rat model, and the kidney injury and serum urate were detected in hyperuricemic mice. Pharmacokinetic result demonstrated that the main apigenin glycosides might be quantitatively transformed into apigenin in the mammalian body. Among these compounds, the apigenin exhibited the strongest effect on xanthine oxidase (XOD). SM aqueous extract has proved to be active in reducing hyperuricemia in dose-dependent manner, and the levels of blood urea nitrogen (BUN) and creatinine (Cr) in high dose group were decreased significantly as compared with hyperuricemic control group (P < 0.01). The high dose of SM extract could significantly prevent the paw swelling, reduce gouty joint inflammatory features, reduce the release of IL-1β and TNF-α, lower malondialdehyde (MDA) and myeloperoxidase (MPO) levels, and increase superoxide dismutase (SOD) level (P < 0.01). For the first time, this study provides a rational basis for the traditional use of SM aqueous extract against gout in folk medicine.

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