Format

Send to

Choose Destination
J Clin Microbiol. 2017 May;55(5):1269-1275. doi: 10.1128/JCM.00017-17. Epub 2017 Mar 1.

Whole-Genome Sequencing in Epidemiology of Campylobacter jejuni Infections.

Author information

1
Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
2
National Microbiology Laboratory at Lethbridge, Animal Diseases Research Institute, Public Health Agency of Canada, Lethbridge, Alberta, Canada.
3
Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland mirko.rossi@helsinki.fi.

Abstract

This review describes the current state of knowledge regarding the application of whole-genome sequencing (WGS) in the epidemiology of Campylobacter jejuni, the leading cause of bacterial gastroenteritis worldwide. We describe how WGS has increased our understanding of the evolutionary and epidemiological dynamics of this pathogen and how WGS has the potential to improve surveillance and outbreak detection. We have identified hurdles to the full implementation of WGS in public health settings. Despite these challenges, we think that ample evidence is available to support the benefits of integrating WGS into the routine monitoring of C. jejuni infections and outbreak investigations.

KEYWORDS:

foodborne pathogens; genome analysis; molecular subtyping; surveillance studies

PMID:
28249998
PMCID:
PMC5405246
DOI:
10.1128/JCM.00017-17
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center