Format

Send to

Choose Destination
PLoS One. 2017 Mar 1;12(3):e0171055. doi: 10.1371/journal.pone.0171055. eCollection 2017.

Role of the APOE polymorphism in carotid and lower limb revascularization: A prospective study from Southern Italy.

Author information

1
Cardiology Unit, Cardiological and Vascular Department, I.R.C.C.S. "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
2
Complex Structure of Geriatrics, Medical Sciences Department, I.R.C.C.S. "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.

Abstract

BACKGROUND:

Atherosclerosis is a complex multifactorial disease and the apolipoprotein E (APOE) polymorphism has been associated to vascular complications of atherosclerosis.

OBJECTIVES:

To investigate the relationship between the APOE genotypes and advanced peripheral vascular disease.

MATERIALS AND METHODS:

258 consecutive patients (201 males and 57 females, mean age 70.83 ± 7.89 years) with severe PVD were enrolled in a 42-months longitudinal study (mean 31.65 ± 21.11 months) for major adverse cardiovascular events. At follow-up genotypes of the APOE polymorphism were investigated in blinded fashion.

RESULTS:

As compared with ε3/ε3, in ε4-carriers a significant higher incidence of major adverse cardiovascular events (35.58% vs. 20.79%; p = 0.025) and total peripheral revascularization (22.64% vs. 5.06%; p < 0.001) was observed. Prospective analysis, showed that ε4-carriers have an increased hazard ratio for major adverse cardiovascular events (adjusted HR 1.829, 95% CI 1.017-3.287; p = 0.044) and total peripheral revascularization (adjusted HR = 5.916, 95% CI 2.405-14.554, p <0.001).

CONCLUSIONS:

The ε4 allele seems to be risk factor for major adverse cardiovascular events, and in particular for total peripheral revascularization in patients with advanced atherosclerotic vascular disease.

PMID:
28249002
PMCID:
PMC5332070
DOI:
10.1371/journal.pone.0171055
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center