Format

Send to

Choose Destination
Results Probl Cell Differ. 2017;59:175-200. doi: 10.1007/978-3-319-44820-6_6.

Translational Control of Germ Cell Decisions.

Author information

1
Regional Centre for Biotechnology, Faridabad, Haryana, India.
2
Indian Institute of Technology-Kanpur, Kanpur, India.
3
Indian Institute of Technology-Madras, Chennai, India.
4
Indian Institute of Technology-Madras, Chennai, India. subbu@iitm.ac.in.

Abstract

Germline poses unique challenges to gene expression control at the transcriptional level. While the embryonic germline maintains a global hold on new mRNA transcription, the female adult germline produces transcripts that are not translated into proteins until embryogenesis of subsequent generation. As a consequence, translational control plays a central role in governing various germ cell decisions including the formation of primordial germ cells, self-renewal/differentiation decisions in the adult germline, onset of gametogenesis and oocyte maturation. Mechanistically, several common themes such as asymmetric localization of mRNAs, conserved RNA-binding proteins that control translation by 3' UTR binding, translational activation by the cytoplasmic elongation of the polyA tail and the assembly of mRNA-protein complexes called mRNPs have emerged from the studies on Caenorhabditis elegans, Xenopus and Drosophila. How mRNPs assemble, what influences their dynamics, and how a particular 3' UTR-binding protein turns on the translation of certain mRNAs while turning off other mRNAs at the same time and space are key challenges for future work.

PMID:
28247049
PMCID:
PMC5985952
DOI:
10.1007/978-3-319-44820-6_6
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center