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Sci Adv. 2017 Feb 15;3(2):e1601966. doi: 10.1126/sciadv.1601966. eCollection 2017 Feb.

Ultraflexible nanoelectronic probes form reliable, glial scar-free neural integration.

Author information

1
Department of Physics, the University of Texas at Austin, Austin, TX 78712-1192, USA.
2
Department of Biomedical Engineering, the University of Texas at Austin, Austin, TX 78712-1192, USA.
3
Center for Learning and Memory, Institute for Neuroscience, the University of Texas at Austin, Austin, TX 78712-1192, USA.

Abstract

Implanted brain electrodes construct the only means to electrically interface with individual neurons in vivo, but their recording efficacy and biocompatibility pose limitations on scientific and clinical applications. We showed that nanoelectronic thread (NET) electrodes with subcellular dimensions, ultraflexibility, and cellular surgical footprints form reliable, glial scar-free neural integration. We demonstrated that NET electrodes reliably detected and tracked individual units for months; their impedance, noise level, single-unit recording yield, and the signal amplitude remained stable during long-term implantation. In vivo two-photon imaging and postmortem histological analysis revealed seamless, subcellular integration of NET probes with the local cellular and vasculature networks, featuring fully recovered capillaries with an intact blood-brain barrier and complete absence of chronic neuronal degradation and glial scar.

KEYWORDS:

biocompatible implant; in vivo imaging; intracortical recording; nanoelectronics; neural electrode; ultra-flexible electronics

PMID:
28246640
PMCID:
PMC5310823
DOI:
10.1126/sciadv.1601966
[Indexed for MEDLINE]
Free PMC Article

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