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Biomed Environ Sci. 2017 Jan;30(1):35-43. doi: 10.3967/bes2017.004.

CDH13 Genetic Polymorphisms, Adiponectin and Ischemic Stroke: a Chinese Family-based Sib-pair Study.

Author information

1
Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing 100191, China.
2
Beijing Center for Disease Prevention and Control, Beijing 100013, China.
3
Department of Epidemiology & Biostatistics, Capital Medical University, Beijing 100069, China.
4
Pingshan New District Center for Disease Control and Prevention, Shenzhen 518118, Guangdong, China.
5
Shilou Township Hospital, Beijing 102422, China.

Abstract

OBJECTIVE:

To understand the relationships between CDH13 (T-cadherin) genetic polymorphisms, adiponectin levels and ischemic stroke, and possible interactions between CDH13 polymorphisms and other risk factors.

METHODS:

We recruited 342 Chinese ischemic stroke sib pairs. We genotyped rs4783244 and rs7193788 on CDH13 using time-of-flight mass spectrometry genotyping technology and measured total and high-molecular weight (HMW) adiponectin levels. We investigated associations between SNPs and ischemic stroke, and interactions between SNPs and other risk factors using multi-level mixed-effects regression model.

RESULTS:

In individuals without ischemic stroke, CDH13 rs4783244 was associated with total adiponectin levels (per T: Coef = -0.257, P = 0.001). CDH13 rs7193788 was associated with total adiponectin levels (per A: Coef = -0.221, P = 0.001) and HMW adiponectin levels (per A: Coef = -0.163, P = 0.003). rs7193788 was significantly associated with ischemic stroke (GA/AA vs. GG: OR = 1.55, 95% CI: 1.07 to 2.24, P = 0.020) after Bonferroni correction (α = 0.025). There was an interaction between rs7193788 and diabetes (P = 0.036). Compared to diabetes-free individuals with rs7193788 GG genotype, diabetes patients with rs7193788 GA/AA genotypes had higher risks for ischemic stroke (OR = 2.64, 95% CI: 1.58-4.40, P < 0.001).

CONCLUSION:

CDH13 genetic polymorphisms are associated with adiponectin levels and ischemic stroke. An interaction is found between CDH13 SNP and diabetes for ischemic stroke.

KEYWORDS:

Adiponectin; CDH13; Genetic polymorphisms; Ischemic stroke; Sib pair

PMID:
28245897
DOI:
10.3967/bes2017.004
[Indexed for MEDLINE]
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