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J Nutrigenet Nutrigenomics. 2016;9(5-6):306-317. doi: 10.1159/000455948. Epub 2017 Mar 1.

The Effect of apoM Polymorphism Associated with HDL Metabolism on Obese Korean Adults.

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1
Department of Food and Nutrition, Sungshin Women's University, Seoul, Republic of Korea.

Abstract

BACKGROUND:

Apolipoprotein M (apoM) is a recently identified apolipoprotein associated with high-density lipoprotein (HDL) in coronary artery disease (CAD), but the association between apoM polymorphism and obesity has not been reported.

AIM:

To investigate the association between apoM polymorphism and obesity prevalence in 584 Korean adults.

METHODS:

A total of 584 individuals aged between 30 and 80 years were recruited from Yonsei Medical Center in Seoul, Korea, and divided into obese (OB; body mass index, BMI ≥25) and nonobese (non-OB; BMI <25) groups. Anthropometric variables, lipid profiles, insulin-resistant profiles, reverse cholesterol transport (RCT) enzymes, HDL subfraction, and apoM polymorphism were determined.

RESULTS:

In OB with T-855C polymorphism, TT genotype carriers significantly showed 6.2% higher diastolic blood pressure (DBP), 1.3% lower amount of HDL2b subfraction, and 19.7% higher lecithin-cholesterol acyltransferase (LCAT) mass than TC+CC carriers. OB subjects with the T allele of T-778C polymorphism significantly demonstrated 43% higher plasma insulin, 17.7% higher total cholesterol, 26.7% higher triglyceride, 40.7% higher leptin, 1.6% lower HDL2b, and 12.6% higher LCAT mass than those with the C allele. These results were reversed in non-OB with T-778C polymorphism regarding HDL subfractions and RCT enzymes.

CONCLUSION:

apoM T-855C and T-778C polymorphisms were found to be associated with obesity by regulating HDL metabolism, and the T alleles of apoM T-778C were shown to be more strongly correlated.

PMID:
28245483
DOI:
10.1159/000455948
[Indexed for MEDLINE]

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