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Mol Nutr Food Res. 2017 Sep;61(9). doi: 10.1002/mnfr.201600984. Epub 2017 Mar 30.

Boswellia serrata resin extract alleviates azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon tumorigenesis.

Author information

1
Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.
2
Department of Food Science and Human Nutrition, Citrus Research and Education Center, University of Florida, Lake Alfred, FL, USA.
3
India Glycols Ltd., Noida, India.
4
American Medical Holdings Incorporated, New York, NY, USA.
5
Department of Food Science, Rutgers University, New Brunswick, NJ, USA.
6
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
7
Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.

Abstract

SCOPE:

Boswellia serrata (BS) resin is a popular dietary supplement for joint nourishment. In this study, we investigated the chemopreventive effects of dietary BS extract and its impact of gut microbiota on azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colitis-associated colon cancer in mice.

METHODS AND RESULTS:

Male ICR mice were injected with AOM and 2% DSS via drinking water. The mice were fed with 0.25 or 0.5% BS extract, and colonic tissue were collected at 15 weeks. The main effective components of BS supercritical CO2 extraction were analyzed by LC-MS/MS are boswellic acids. We found that treatment with BS extract significantly reduce the colonic tumor formation. Western blot and histological analysis revealed that dietary BS extract could markedly reduce the inflammation associated protein levels expression. Furthermore, BS extract reduced cell proliferation via inhibiting phosphorylation level of protein kinase B (Akt), glycogen synthase kinase 3β (GSK3β), and downregulation of cyclin D1. In addition, BS extract also altered the composition of gut microbiota by enhancing the proportion of Clostridiales and reducing the percentage of Bacteroidales.

CONCLUSION:

In summary, BS extract decreased the protein levels of inflammative enzymes such as inducible nitric oxide synthase and cyclooxygenase-2 in colonic mucosa. It also mediated Akt/GSK3β/cyclin D1 signaling pathway and altered the composition of gut microbiota to alleviate tumor growth. Taken together, this study suggests that BS extract has great potential to suppress colon tumorigenesis.

KEYWORDS:

Azoxymethane; Boswellia Serrata; Colorectal cancer; Dextran sulfate sodium; Inflammation

PMID:
28245338
DOI:
10.1002/mnfr.201600984
[Indexed for MEDLINE]

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