PDGF-like growth factors in autocrine stimulation of growth

J Cell Physiol Suppl. 1987:Suppl 5:31-4. doi: 10.1002/jcp.1041330407.

Abstract

PDGF is a dimeric molecule consisting of A chains and B chains. All three dimeric combinations have been found in platelets, or produced by certain normal or transformed cell types; whether functional differences occur between different dimers is currently under investigation. Production of PDGF-like factors by cells carrying PDGF receptors may establish an autocrine loop, driving cell multiplication.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Division / drug effects*
  • Cell Transformation, Neoplastic / drug effects
  • Cell Transformation, Viral / drug effects
  • Gene Expression Regulation
  • Humans
  • Mitosis / drug effects
  • Platelet-Derived Growth Factor / genetics
  • Platelet-Derived Growth Factor / pharmacology*
  • Sarcoma Virus, Woolly Monkey / genetics
  • Structure-Activity Relationship

Substances

  • Platelet-Derived Growth Factor