Abstract
PDGF is a dimeric molecule consisting of A chains and B chains. All three dimeric combinations have been found in platelets, or produced by certain normal or transformed cell types; whether functional differences occur between different dimers is currently under investigation. Production of PDGF-like factors by cells carrying PDGF receptors may establish an autocrine loop, driving cell multiplication.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Cell Division / drug effects*
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Cell Transformation, Neoplastic / drug effects
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Cell Transformation, Viral / drug effects
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Gene Expression Regulation
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Humans
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Mitosis / drug effects
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Platelet-Derived Growth Factor / genetics
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Platelet-Derived Growth Factor / pharmacology*
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Sarcoma Virus, Woolly Monkey / genetics
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Structure-Activity Relationship
Substances
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Platelet-Derived Growth Factor