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Nat Methods. 2017 Feb 28;14(3):228-232. doi: 10.1038/nmeth.4185.

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research.

Author information

1
Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.
2
Center for Medical Genetics, Cancer Research Institute Ghent (CRIG), Bioinformatics Institute Ghent (BIG), Ghent University, Ghent, Belgium.
3
Cell Death Research &Therapy (CDRT) Lab, KU Leuven University of Leuven, Leuven, Belgium.
4
Department of Biomedical Molecular Biology, Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.
5
Molecular and Cellular Oncology Lab, Inflammation Research Center, VIB, Ghent, Belgium.
6
Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.
7
Unidad de Investigación, Hospital Santa Cristina Instituto de Investigación Sanitaria Princesa C, Madrid, Spain.
8
Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Rommelaere Campus, Ghent, Belgium.
9
Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
10
Institute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
11
Animal Physiology and Immunology, School of Life Sciences, Technical University of Munich (TUM) Weihenstephan, Freising, Germany.
12
Laboratory of Cytometry, Department of Internal Medicine, University of Michigan Medical School, University of Michigan, Ann Arbor, Michigan, USA.
13
Department of Biochemistry, Nencki Institute of Experimental Biology, Warsaw, Poland.
14
Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
15
Faculty of Sciences, Division of Biochemistry, Chemistry Department, Damietta University, New Damietta City, Egypt.
16
UMR-1280, INRA, University of Nantes, Physiologie des Adaptations Nutritionnelles, Nantes, France.
17
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
18
Inflammation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
19
Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.
20
Research Unit Gene Vectors, Helmholtz Zentrum München, Munich, Germany.
21
German Centre for Infection Research (DZIF), partner site Munich, Munich, Germany.
22
Department of Molecular and Comparative Pathobiology and Department of Neurology, The Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
23
INSERM U1109, MN3T, Strasbourg, France.
24
LabEx Medalis, Université de Strasbourg, Strasbourg, France.
25
Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France.
26
Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
27
Institut Curie, PSL Research University, INSERM U932, Paris, France.
28
Department of Thoracic and Cardiovascular Surgery, University Hospital RWTH Aachen, Germany.
29
Institute of Human Genetics, Saarland University, Homburg, Germany.
30
German Center for Neurodegenerative Diseases Bonn (DZNE e.V.), Bonn, Germany.
31
Institut Curie, PSL Research University, CNRS, UMR 144, Paris, France.
32
Université Côte d'Azur, Inserm, CNRS, iBV, Nice, France.
33
REMAR-IVECAT Group, Germans Trias i Pujol Health Science Research Institute, Can Ruti Campus, Autonomous University of Barcelona, Barcelona, Spain.
34
Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
35
School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
36
Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
37
Laboratory of Lipid Metabolism and Cancer, Department of Oncology, LKI - Leuven Cancer Institute, KU Leuven University of Leuven, Leuven, Belgium.
38
Biochemistry and Biotechnology, Faculty of Biological and Environmental Sciences and Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Finland.
39
Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.

Abstract

We argue that the field of extracellular vesicle (EV) biology needs more transparent reporting to facilitate interpretation and replication of experiments. To achieve this, we describe EV-TRACK, a crowdsourcing knowledgebase (http://evtrack.org) that centralizes EV biology and methodology with the goal of stimulating authors, reviewers, editors and funders to put experimental guidelines into practice.

PMID:
28245209
DOI:
10.1038/nmeth.4185
[Indexed for MEDLINE]

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