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J Agric Food Chem. 2017 Mar 22;65(11):2315-2322. doi: 10.1021/acs.jafc.6b05679. Epub 2017 Mar 8.

Oral Ingestion of Collagen Hydrolysate Leads to the Transportation of Highly Concentrated Gly-Pro-Hyp and Its Hydrolyzed Form of Pro-Hyp into the Bloodstream and Skin.

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Research Institute, FANCL Corporation , 12-13 Kamishinano, Totsukaku, Yokohama, Kanagawa 244-0806, Japan.
Department of Molecular Biology, Graduate School of Medical Science, Yokohama City University , 3-9 Fuku-ura, Kanazawaku, Yokohama 236-0004, Japan.


Collagen hydrolysate is a well-known dietary supplement for the treatment of skin aging; however, its mode of action remains unknown. Previous studies have shown that the oral ingestion of collagen hydrolysate leads to elevated levels of collagen-derived peptides in the blood, but whether these peptides reach the skin remains unclear. Here, we analyzed the plasma concentration of collagen-derived peptides after ingestion of high tripeptide containing collagen hydrolysate in humans. We identified 17 types of collagen-derived peptides transiently, with a particular enrichment in Gly-Pro-Hyp. This was also observed using an in vivo mouse model in the plasma and skin, albeit with a higher enrichment of Pro-Hyp in the skin. Interestingly, this Pro-Hyp enrichment in the skin was derived from Gly-Pro-Hyp hydrolysis, as the administration of pure Gly-Pro-Hyp peptide led to similar results. Therefore, we propose that functional peptides can be transferred to the skin by dietary supplements of collagen.


Gly-Pro-Hyp; Pro-Hyp; collagen; dietary supplement; kinetics; peptide

[Indexed for MEDLINE]

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