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J Korean Med Sci. 2017 Apr;32(4):628-635. doi: 10.3346/jkms.2017.32.4.628.

Effects of Vitamin and Antioxidant Supplements in Prevention of Bladder Cancer: a Meta-Analysis of Randomized Controlled Trials.

Park SJ1,2, Myung SK1,3,4,5, Lee Y1, Lee YJ6.

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Department of Family Medicine, National Cancer Center, Goyang, Korea.
Department of Family Medicine, Yonsei University Graduate School, Seoul, Korea.
Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.
Molecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention, Research Institute, National Cancer Center, Goyang, Korea.
Center for Cancer Prevention and Detection, Hospital, National Cancer Center, Goyang, Korea.
Department of Family Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Korea.


This study aimed to investigate the effects of vitamin and antioxidant supplements in the prevention of bladder cancer using a meta-analysis of randomized controlled trials (RCTs). Fourteen RCTs were included in the final analysis. In a fixed-effect meta-analysis, vitamin and antioxidant supplements showed no preventive effect for bladder cancer (relative risk [RR] = 1.04; 95% confidence interval [CI] 0.92-1.17; I² = 39.7%). Also, there was no preventive effect of these supplements in the subgroup meta-analyses by various factors such as type of supplements, type of cancer prevention, methodological quality, providers of supplements, type of control group, and number of participants. Among the subgroup analyses by type of supplements, beta-carotene supplementation alone marginally increased the risk of bladder cancer (RR = 1.44; 95% CI 1.00-2.09; I² = 0.0%; n = 3). The current meta-analysis found that vitamin and antioxidant supplements have no preventive effect against bladder cancer.


Antioxidant; Bladder Cancer; Meta-Analysis; Randomized Controlled Trials; Vitamin

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