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J Nat Med. 2017 Jul;71(3):553-557. doi: 10.1007/s11418-017-1078-5. Epub 2017 Feb 27.

Two new secolignans with in vitro anti-inflammatory activities from Urtica fissa rhizomes.

Author information

1
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China.
2
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China. mywang@sjtu.edu.cn.
3
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China. xbli@sjtu.edu.cn.
4
Enthomedicine Research Center, Yunnan Dali Research Academy of Shanghai Jiao Tong University, Dali, 671000, China. xbli@sjtu.edu.cn.

Abstract

Two new secolignans, urticin A (1) and urticin B (2), were isolated from the ethanol extract of Urtica fissa rhizomes. Their structures were elucidated on the basis of extensive spectroscopic evidence (UV, IR, HR-ESI-MS, and NMR). Urticin A and urticin B possessed in vitro anti-inflammatory activities, which significantly inhibited the TNF-α and NO release induced by LPS in RAW 264.7 cells.

KEYWORDS:

Anti-inflammatory; Secolignan; Urtica fissa; Urticaceae

PMID:
28243817
DOI:
10.1007/s11418-017-1078-5
[Indexed for MEDLINE]

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